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Scientists developing diagnostic test which aims to detect antibiotic resistance in less than 45 minutes

29/10/2019

Scientists developing diagnostic test which aims to detect antibiotic resistance in less than 45 minutes

Scientists are developing a low cost, rapid diagnostic sensor test which aims to show the susceptibility of bacteria to antibiotics within 45 minutes.

NHS laboratory testing of samples can take up to two days and the new test aims to allow doctors to be able to prescribe the correct antibiotic to a patient for an infection more quickly.

In a research paper published in the journal Biosensors and Bioelectronics, the University of Strathclyde team has demonstrated the system is capable of showing results in less than 45 minutes.

The scientists examined the difference in growth profiles between the common hospital acquired bacterial infections, Staphylococcus aureus, most strains of which are sensitive to antibiotics, and the drug resistant strain, MRSA, which is resistant to several widely used antibiotics and can be harder to treat.

Both strains were placed onto electrodes covered in a special hydrogel deposit which monitored bacterial growth and which also contained antibiotics.

Results showed that the susceptible strain can grow on electrodes modified with gel containing no antibiotic, but could not grow when the sensor was seeded with antibiotic. However, due to its antibiotic resistance, the MRSA strain was still able to grow on the electrodes which contained clinically relevant concentrations of antibiotics.

Find out more about the work on the MRC news story: Scientists developing diagnostic test which aims to detect antibiotic resistance in less than 45 minutes.


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