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The impact of COVID-19 in pregnancy

Impact of COVID-19 in pregnancy graphic

As pregnant women across the globe face uncertainty with COVID-19, the Medical Research Council (MRC) has funded several studies to investigate the potential impacts of COVID-19 at all stages of pregnancy.

Pregnant women around the world have faced increased uncertainty with the arrival of COVID-19, the disease caused by the novel SARS-CoV-2 coronavirus.

Scientists have identified ‘significant knowledge gaps’ in the impact of COVID-19 on mothers’ and babies’ health at all stages of pregnancy. In the UK, pregnant women were added to the list of people moderately at risk from coronavirus as a precautionary measure.

Knowing more about the virus’s impact on pregnancy is vital for treatment and prevention: the SARS and MERS outbreaks resulted in over 25% case fatality in pregnant women, with worse effects for those infected earlier in their pregnancy.

Creating a global registry

Professor Christoph Lees and Dr Ed Mullins from Imperial College are leading a study co-funded by the MRC and the National Institute for Health Research to answer key questions about the impact of COVID-19 on pregnancy outcomes.

Dr Mullins said:

Key questions about pregnancy during the pandemic are whether the SARS-CoV-2 virus is associated with miscarriage, stillbirth and pre-term labour. We are also unclear if the virus gets transmitted from mothers to babies.

This study will rapidly collect information on women in pregnancy and their babies affected by the virus from around the world.

Through regular online updates and collaboration with other studies, we will improve our collective understanding of the infection in pregnancy and learn how we can lessen its impact.

They are investigating the effects of the SARS-CoV-2 virus in early pregnancy, the impact on foetal growth, prematurity and virus transmission to the baby, in collaboration with colleagues at Cardiff University and the International Society of Ultrasound in Obstetrics and Gynecology.

The team is building a registry of women with suspected and confirmed COVID-19, from early pregnancy to after the delivery of the baby. Healthcare professionals from the UK, Europe, China and the USA will contribute anonymised data via a web portal.

The health and wellbeing of pregnant women and new parents

Led by Dr Josie Dickerson, the Born in Bradford team at Bradford Teaching Hospital Foundation Trust is working to find out how the changes in healthcare and social distancing in the pandemic have impacted the health and wellbeing of women and their partners:

  • during pregnancy
  • at birth
  • in the first year after having a baby.

Born in Bradford is a long-term cohort study and the only research programme in the UK that is currently recruiting into two birth cohorts

  • Born in Bradford’s Better Start (BiBBS), which focuses on women living in ethnically diverse and deprived communities
  • BiB4All, a routine data linkage birth cohort study aiming to recruit all pregnant women booked to give birth at Bradford Teaching Hospitals NHS Foundation Trust.

This infrastructure will allow the team to recruit 1,800 pregnant women and their partners over the coming year and follow up throughout the perinatal period.

Dr Dickerson and her team will use a mixed-method approach of large-scale surveys and in-depth qualitative research to understand new parents’ experiences and concerns related to COVID-19, and their ability to access the health and social support they need.

They will also look at the impact of the pandemic on food, housing and income security, and self-reported physical and mental health.

Dr Dickerson said:

The NHS has identified pregnant women as high risk during the COVID-19 crisis. The additional stress alongside poor or fragmented care and social support may have profound effects on the health and wellbeing of women, their babies and their partners.

This research will inform practitioners, service providers and policymakers where intervention is needed to reduce these adverse effects in the short term, and as part of recovery.

Rapid analysis in combination with routine primary care, maternity, health visiting social care and education data will help provide timely information on areas where action is needed. Longer-term follow-up analysis will be of major scientific and policy significance.

The MRC has now committed almost £3 million of funding to Born in Bradford’s second wave, which runs from 2016 to 2021.

Last updated: 28 October 2020

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