Researchers worldwide can apply to access advanced structural biology techniques through Instruct, a pan-European distributed research infrastructure. Researchers in member countries and organisations can receive funding for this access, as well as internship opportunities, training courses, and research and development funding.
Instruct’s mission is to drive innovation in biomedical science by fostering collaboration, offering state-of-the-art resources, and ensuring equitable access to scientific tools for researchers across the globe. Through collaboration, integrated structural biology studies can be conducted that leverage the potential of multiple different structural biology technologies.
Instruct operates on a non-economic basis within the framework of the European Research Infrastructure Consortium (ERIC) regulation.
Strengthening global collaborations
Instruct-ERIC applied for Horizon Europe funding to strengthen collaborations with research infrastructures in complementary disciplines. The funding allowed them to broaden the network and improve the quality of services provided to researchers worldwide.
It has also allowed them to support thematic research in key biomedical fields, including:
- cancer
- antiviral medication
- infectious diseases
- translational research
This has ensured dedicated access to essential technologies in these critical areas.
In addition, they have been able to extend collaborations even further by working with research teams and institutions in third countries. This has strengthened its global reach and helped create an international research community, while solving some of the most pressing challenges in structural biology and biomedical science.
Support and guidance during the application process
During its early development and initial applications for Horizon Europe projects, Instruct-ERIC received valuable support from the University of Oxford. The expertise provided by the university played a crucial role in navigating the complexities of the application process, helping them to secure funding and establish its presence within the European research infrastructure.
As the organisation grew, it developed the capability to manage applications independently, supported by ERIC partners and an ever-expanding network of research institutions across Europe and beyond. This evolution reflects their commitment to continuous improvement and its ability to adapt to the changing research landscape.
The value of being an ERIC
Establishing Instruct as ERIC has been a significant milestone, and the framework has strengthened Instruct-ERIC’s infrastructure and research collaborations, allowing scientists to collaborate across borders to tackle complex biological questions. This collaborative environment has led to breakthroughs in medical and life sciences, making them a vital player in the global scientific community.
Instruct’s director Professor Schwalbe from Goethe-University Frankfurt states:
Horizon Europe grants build on the expertise of ERICs to bring together expertise of the strongest researchers and accessibility to the most modern technologies. As we have connections with the European and global structural biology community, but also with the wider research infrastructures and ERIC communities through platforms such as the ERIC Forum, we are a valuable asset in Horizon projects.
In March 2025 Instruct was recognised for their commitment to gender equality and diversity and were awarded the EU Award Gender Equality Champions Prize 2024 in the ‘Newcomer’ category. As an international institution, ERIC can thus support and promote gender equality in its centres and research sites.
Validation of excellence
ERIC membership serves as a validation of excellence. The inclusion of Instruct-ERIC’s facilities within the ERIC network highlights the high calibre of research conducted at its centres. This recognition has further strengthened their ability to attract leading structural biology researchers, ensuring that Instruct facilities remain at the forefront of scientific discovery.
They maintain strong connections with industrial partners across the UK and Europe and have welcomed sponsors to their biennial conferences and collaborated with industrial companies through Horizon Europe projects, such as Fragment-Screen. This project is coordinated by Instruct and involves several industry partners, including Astex in the UK.
Building an international consortium and its benefits
A fundamental aspect of Instruct-ERIC’s success lies in its ability to engage with the structural biology community. By establishing a network of research centres and technology providers, the organisation has ensured access to a diverse and high-quality range of structural biology services, maintaining excellence through collaboration.
Beyond providing access to advanced research facilities, Instruct-ERIC has actively expanded its consortium, welcoming new countries and organisations. By 2025, membership has grown to 17 institutions, with ongoing efforts to increase participation and broaden access to world-class technologies through funded programmes.
Working with international partners fosters a global research community. Structural biology thrives on cross-border collaboration, and Instruct-ERIC’s efforts have strengthened connections, creating a more dynamic and inclusive research environment. A key goal is to democratise access to high-end technologies, ensuring researchers worldwide can utilise cutting-edge equipment and share expertise.
This commitment to accessibility and collaboration has positioned Instruct-ERIC as a leader in the global scientific community.
Instruct-ERIC 2024 biennial 2024 group photo. Credit: Instruct-ERIC 2024
Future funding plans and advice for new applicants
Looking ahead, Instruct-ERIC remains dedicated to securing further Horizon Europe funding. By maintaining strong relationships with the research community and actively seeking new opportunities, the organisation will continue to provide essential resources for structural biology researchers.
To maintain its competitive edge, Instruct will continue to rely on the national membership fees of its European members. Given the impact of structural biology in solving urgent challenges of a globally interconnected society, we seek to increase the national support for Instruct in its next funding cycle commencing 2027.
Expanding funding sources will also enable them to support more thematic research initiatives, ensuring that scientists have access to the technologies needed to drive innovation in biomedical science. With an eye on the future, Instruct-ERIC aims to build upon its existing successes and further strengthen its role within the international research landscape.
Invaluable insights and expertise
By partnering with experienced research infrastructures, it can provide invaluable insights and expertise, strengthening the overall quality of project proposals. Combining detailed knowledge from specific research fields with the established capabilities of larger infrastructures, applicants can create compelling projects that have a lasting impact on the European research ecosystem.
Additionally, organisations should be proactive in engaging with potential partners and funding bodies early in the application process. Establishing clear objectives and demonstrating how a project aligns with broader research priorities can significantly improve the chances of securing funding.
Rewards and recognition
Through its strategic use of Horizon Europe funding, Instruct-ERIC has:
- expanded its reach
- strengthened its infrastructure
- created a more inclusive and collaborative research environment for structural biology
Its success serves as a testament to the power of international cooperation in advancing scientific innovation. As it continues to grow and evolve, Instruct-ERIC remains committed to supporting researchers worldwide, ensuring they have access to the technologies and networks needed to drive groundbreaking discoveries in biomedical science.
Top image: Credit: Instruct-ERIC 2024