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MRC: Infections and immunity programme grant: Jan 2021

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Programme grants provide large, long-term and renewable programme funding for researchers working in the area of infections and immunity research. They aim to help the medical science community to ‘think bigger’:

  • we award programme grants to UK-based research organisations
  • applications are typically for funding of £1 million or more
  • programmes last up to five years
  • we will usually fund up to 80% of your project’s full economic cost
  • programme grants are usually based within an academic institution which has the variety of expertise and disciplines to undertake the programme.

Next round opens: 12 November 2020

Who can apply

Any UK-based researcher with an employment contract at an eligible research organisation can apply for a programme grant. You will need to show that you will direct the proposed research yourself and be actively involved in the work.

You must have:

  • a graduate degree, although we expect most applicants to have a PhD or medical degree
  • a substantial record of securing research funding and delivering high-quality research.

You can include one or more industry partners as project partners in your application.

You can also include international co-investigators if they provide expertise that is not available in the UK.

You are not eligible to apply for a programme grant if you are:

  • from a Medical Research Council institute
  • a core-supported programme/group leader from MRC units and the Francis Crick Institute.

A principal investigator can usually hold only one programme grant at a time.

The focus of this funding opportunity is infections and immunity research. There are similar opportunities across other areas of medical research within our remit, including molecular and cellular medicine, population and systems medicine, neurosciences and mental health, and applied global health. There are also other types of awards including research, partnerships and new investigator.

You should contact us if you are not sure which opportunity to apply to.

What we're looking for

The MRC’s Infections and Immunity Board funds research into infectious human disease and disorders of the human immune system. The board supports a diverse portfolio of research of relevance to the UK and globally, and to address both long-standing questions and support the investigation of emerging higher-risk opportunities.

Research we fund includes, but is not limited to, the following areas:

  • discovery research relating to human pathogens, pathogenicity, antimicrobial resistance, host pathogen responses including inflammation and the development function and disorders of the immune system where this informs mechanism of disease. Immune disease including allergy (except asthma and other organ-based disorders), transplantation immunology, systemic immune disorders and auto-immune disease. Including use of in silico systems, relevant animal models and experimental studies in humans throughout the lifecourse
  • population-level research, using epidemiological, genetic and ‘omic approaches, and computational modelling, to elucidate disease risks, aetiologies and progression, and to understand the evolution of pathogen populations and epidemic preparedness
  • research to inform novel strategies for preventing and controlling infectious and immune disease, including vector control, predictive modelling and early development research to inform future intervention strategies including vaccines.

Find out more about the science areas we support and our current board opportunity areas.

We encourage you to contact us first to discuss your application if you believe your research may cross MRC research board or research council interests. If your application fits another research board remit better we may decide to transfer it there to be assessed.

We define a programme as a coordinated and coherent group of related projects. You may develop these projects to address an interrelated set of questions across a broad scientific area.

We do not expect you to find answers to all these questions within the duration of the grant. Parts of the programme may be a continuation of current activity, but we expect other elements to be innovative and ambitious.

Programmes are a large investment for the MRC, so we expect you to show how your application fits within MRC strategy.

You can request funding for costs such as:

  • a contribution to the salary of the principal investigator and co-investigators
  • support for other posts such as research and technical
  • research consumables
  • equipment
  • travel costs
  • data preservation, data sharing and dissemination costs
  • estates/indirect costs.

We won’t fund:

  • research involving randomised trials of clinical treatments
  • funding to use as a ‘bridge’ between grants
  • costs for PhD studentships
  • publication costs.

How to apply

Application deadlines for Infections and Immunity Board funding are usually around January, May and September, although sometimes launch and application deadlines can change, so check the Funding finder for details.

You can submit to any of the available deadlines in the year. We do not expect you to submit more than two applications at the same time and encourage you to focus on application quality, not the number you can submit. Read our guidance for applicants for details of our resubmission process.

Pre-application stage (new programmes)

The standard of applications for programme grants is very competitive. You must contact the relevant programme manager before you apply to check if your proposal is suitable. You must do this at least six weeks before the deadline:

You should email the programme manager, attaching a brief description of your proposal. The document should be no more than two pages, plus one page of references, and include:

  • the title of the potential programme
  • a list of the principal investigator and co-investigators and their affiliations
  • a list of collaborators (if known at this stage)
  • an estimate of the likely cost to the MRC.

You should answer the following questions on the suitability of your proposal for a programme grant. You should also address its strategic fit and suitability for a major investment:

  • is the proposed work a programme (a coordinated and coherent group of related projects to answer an interrelated set of questions)?
  • does the work need long-term and extensive support?
  • is the proposed work in an MRC area of high strategic priority?
  • is there a case for a major investment in the context of the board portfolio and budget?
  • do you have a track record that shows you have the potential to successfully manage and deliver a major research programme?

It is important that you clearly state your aims, but we do not expect this initial document to contain detailed research proposals.

You must also attach:

  • a CV (no more than two pages of A4)
  • a list of publications for the principal investigator and co-investigators (one-page A4 only)
  • a summary of the principal investigator’s funding history. We will assess your track record of research and potential to manage and deliver a major research programme.

Population cohorts

If your application is to fund new or existing population cohort studies, you must first submit an outline to the Cohort Strategic Review Group. Outline applications are not needed for clinical (patient-specific or disease-focused) cohorts.

Full application stage (new programmes and renewals)

We may invite you to complete a full application via our online Joint Electronic Submission system (Je-S). We will do this in advance of the relevant closing date.

If you are submitting a new application, you should include a cover letter confirming the name of the programme manager who agreed you could apply. If you are applying to renew your grant, the cover letter should include details of the original grant.

You should read section 2 of the MRC guidance for applicants for information on how to complete the application.

Industrial partners

If you want to include one or more industry partners as a project partner, you must also:

  • complete the project partner section in Je-S
  • submit an MRC industrial collaboration agreement (MICA) form and heads of terms
  • include ‘MICA’ as a prefix to your project title.

Find out more about MRC industry collaboration agreements.

Case for support

The list below covers specific points that you should address when writing your case for support. It also provides details of what reviewers and research board members are looking for.

You should read the list in conjunction with the general guidance in section 2.2.3 of the MRC guidance for applicants.

You must provide the following in your case for support:

Importance

  • State the aims of the programme
  • Justify why you cannot fund the programme in other ways
  • Explain why it is appropriate to establish a programme in this scientific area
  • Explain how establishing a programme will help increase your productivity and create added value
  • Show the significance of the programme for this area(s) of research
  • Explain how the programme will improve the UK’s international standing in this area

Scientific potential

  • Participants in the programme and existing funding
    • You must provide a brief report on the progress of your recent research, including any preliminary data relevant to the programme
    • What is the scale of support provided? This does not have to be detailed; for instance, the number of post-doctorates and/or technicians supported together with the total amount of consumables and equipment provided over the course of the grant
  • Environment
    • Describe the environment(s) in which the programme will take place
    • If the proposal is for shared equipment or expertise, describe where this will be and how the host organisation will support it. Also describe the management arrangements for ensuring equity of access
    • Describe the host research organisation’s support for the programme
  • Research plans
    • Give details of the general experimental approaches, study designs and techniques that you will use. You do not need to describe each experiment, but give enough detail to show why the research is likely to be competitive in its field. For example:
      • highlight plans which are particularly original or unique
      • describe all foreseeable human studies and animal experiments (in as much detail as possible at this stage)
      • explain in greater detail how you will approach new techniques, or particularly difficult or risky studies, and alternative approaches if these fail
      • identify facilities or resources you will need to access.
    • Give sufficient detail to justify the resources requested

Ethics and research governance

You must follow the guidance in section 2.2.3.3 of the MRC guidance for applicants (case for support content)

Exploitation and dissemination

You must follow the guidance in section 2.2.3.3 of the MRC guidance for applicants (case for support content)

Management

Provide a simple explanation of how you will manage the programme

Programme grant renewals: extra requirements

You must provide a progress report with an application for renewal. You should attach this as a PDF file to your Je-S application as a ‘final/interim report’ attachment type.

You must use the following set of headings:

  • title
  • summary (not exceeding 250 words)
  • progress (no more than five pages)
    • describe progress made against original aims and objectives since the grant was awarded or since the last report
    • any unpublished data must be included in the case for support.

You should include with the progress report:

  • a list of publications arising from this work, including web links to online papers
  • a list of staff employed on the grant up to the current date.

Applying through Je-S

You must apply through the Joint Electronic Submission system (Je-S). Please read the Je-S how to apply guidance (PDF, 190KB) for more information. If you need help in applying, you can contact Je-S on 01793 444164 or by email JeSHelp@je-s.ukri.org.

You should give your administrative department sufficient notice that you intend to apply. Your organisation must submit your application before 16:00 on the deadline date.

How we will assess your application

When we receive your application, it will be peer-reviewed by independent experts from the UK and overseas.

You can nominate up to three independent reviewers. We will invite only one to assess your research proposal, and may decide not to approach any of your nominated reviewers.

Peer reviewers will assess your application and provide comments. They will also score it using the peer reviewer scoring system against the following criteria:

  • importance: how important are the questions, or gaps in knowledge, that are being addressed?
  • scientific potential: what are the prospects for good scientific progress?
  • resources requested: are the requested funds essential for the work? And do the importance and scientific potential justify funding on the scale requested? Does the proposal represent good value for money?

Read the detailed assessment criteria for each grant type.

We will review these scores and comments at a triage meeting and expect to continue with the highest quality applications with potential to be funded. If your application passes the triage stage, we will give you the chance to respond to reviewers’ comments.

A board meeting will then discuss your proposal and decide if it is suitable for funding. We make a decision within six months of receiving your application.

Find out more about our peer review process.

Contact details

Visit our science contacts page or contact the programme manager most relevant to your research area for advice on developing your application and which board to apply to:

Other contacts:

For general queries about MRC policy and eligibility or if you are not sure who to contact, get in touch with our research funding policy and delivery team:

Additional info

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