The aim of this cross-council initiative is to address one of the key gaps in our understanding of the role of the outdoor and host environments in antimicrobial resistance in the real world.
Antimicrobial resistance (AMR) is recognised as one of the most important global issues for human and animal health in terms of societal impact. One of the key gaps in our understanding of AMR is the role of the outdoor and host environments. To address this, the Natural Environment Research Council (NERC) is leading a call on ‘AMR in the real world’ on behalf of the AMR Cross-Council Initiative. This programme is part of UKRI’s cross-council initiative on fighting AMR.
Research funded under the programme will examine the role of the environment and host microbiome in influencing the evolution, acquisition and spread of antibacterial resistance, and as a reservoir for resistance.
The focus will be antibacterials and resistant bacteria or resistance genes, of relevance to bacteria of clinical and veterinary importance. Research will be supported in the agricultural, aquaculture, wastewater and natural environments (freshwater, marine, soil, air and their interfaces), and will also include elements of the way people and communities interact with the environment.
The AMR cross-council initiative is led by the Medical Research Council (MRC) on behalf of the research councils and will be delivered through a thematic approach, with research to be commissioned under four themes:
- Understanding resistant bacteria
- Accelerating therapeutic and diagnostics development
- Understanding the real world interactions
- Behaviour within and beyond the health care setting
This programme, ‘AMR in the real world’, falls under the third theme of the AMR cross-council initiative – Understanding the real world interactions.
The theme aims to address the need for a greater understanding of the role of the bacterial environment, defined in the broad sense, in influencing the evolution, acquisition and spread of antibacterial resistance, and as a reservoir of resistance.