4. Proposals involving animal use - MRC


4.1 Replacement, reduction and refinement of animal experiments

Applicants are expected to have developed their proposals in accordance with the cross-funder guidance for the use of animals in research: responsibility in the use of animals in bioscience research and NC3Rs guidelines: primate accommodation, care and use.

Experiments using animals funded by the MRC must comply with the Animals (Scientific Procedures) Act 1986 (ASPA), amended 2012 and any further embodiments, in:

  • using the simplest possible, or least sentient, species of animal appropriate
  • ensuring that distress and pain are avoided wherever possible
  • employing an appropriate design and using the minimum number of animals consistent with ensuring that scientific objectives will be met.

Advice on opportunities and techniques for implementing these principles can be found on the NC3Rs website. This includes the Experimental Design Assistant (EDA), a free online tool from the NC3Rs to help optimise experimental design and ensure that the number of animals used is consistent with the scientific objectives.

Last updated: 17 August 2021

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