We are running this funding opportunity on the new UK Research and Innovation (UKRI) Funding Service so please ensure that your organisation is registered. You cannot apply on the Joint Electronic Submissions (Je-S) system.
Intent to apply
If you are intending to apply to this funding opportunity, you should note there is a restriction of one institution level application, per eligible research organisation. We therefore advise you firstly contact your research office to discuss your application, before starting your application. This will ensure only one funding application will be submitted by your research organisation.
After discussing your intention to apply, there is a mandatory requirement that you provide us the following information:
- your details (name and research organisation) and confirm your intent to apply as the project lead
- confirming your application will be the only application submitted by your research organisation
- the details of your core leadership team
- a summary of your application (max 550 words)
Based on this information we may advise you whether your application is suited to this funding opportunity.
Email: humandiseasemodels@mrc.ukri.org with the information required.
The closing date to email us with your intent to apply is 15 April 2026.
Full application
The project lead is responsible for completing the application process on the Funding Service, but we expect all team members and project partners to contribute to the application.
Only the lead research organisation can submit an application to UKRI.
There is a restriction allowing a maximum of one application per eligible research organisation.
To apply
Select ‘Start application’ near the beginning of this Funding finder page.
- Confirm you are the project lead.
- Sign in or create a Funding Service account. To create an account, select your organisation, verify your email address, and set a password. If your organisation is not listed, email support@funding-service.ukri.org
Please allow at least 10 working days for your organisation to be added to the Funding Service. We strongly suggest that if you are asking UKRI to add your organisation to the Funding Service to enable you to apply to this opportunity, you also create an organisation Administration Account. This will be needed to allow the acceptance and management of any grant that might be offered to you.
- Answer questions directly in the text boxes. You can save your answers and come back to complete them or work offline and return to copy and paste your answers. If we need you to upload a document, follow the upload instructions in the Funding Service. All questions and assessment criteria are listed in the How to apply section on this Funding finder page.
- Allow enough time to check your application in ‘read-only’ view before sending to your research office.
- Send the completed application to your research office for checking. They will return it to you if it needs editing.
- Your research office will submit the completed and checked application to UKRI.
Please be aware that research office and finance teams undertake checks on hosting arrangements and financial eligibility. The ultimate responsibility for ensuring compliance with all opportunity requirements lies with the applicant.
Where indicated, you can also demonstrate elements of your responses in visual form if relevant.
When including images, you must:
- provide a descriptive caption or legend for each image immediately underneath it in the text box (this must be outside the image and counts towards your word limit)
- insert each new image on a new line
- use files smaller than 5MB and in JPEG, JPG, JPE, JFI, JIF, JFIF, PNG, GIF, BMP or WEBP format
Images should only be used to convey important visual information that cannot easily be put into words. The following are not permitted, and your application will be rejected if you include:
- sentences or paragraphs of text
- tables
- excessive quantities of images
A few words are permitted where the image would lack clarity without the contextual words, such as a diagram, where text labels are required for an axis or graph column.
For more guidance on the Funding Service, see:
References
References should be included within the word count of the appropriate question section. You should use your discretion when including references and prioritise those most pertinent to the application.
Hyperlinks can be used in reference information. When including references, you should consider how your references will be viewed and used by the assessors, ensuring that:
- references are easily identifiable by the assessors
- references are formatted as appropriate to your research
- persistent identifiers are used where possible
General use of hyperlinks
Applications should be self-contained. You should only use hyperlinks to link directly to reference information. You must not include links to web resources to extend your application. Assessors are not required to access links to conduct assessment or recommend a funding decision.
Generative artificial intelligence (AI)
Use of generative AI tools to prepare funding applications is permitted, however, caution should be applied.
For more information see our policy on the use of generative AI in application and assessment.
Deadline
MRC must receive your application by 21 May 2026 at 4:00pm UK time.
You will not be able to apply after this time.
Make sure you are aware of and follow any internal institutional deadlines.
Following the submission of your application to this funding opportunity, your application cannot be changed, and submitted applications will not be amended. If your application does not follow the guidance, it may be rejected.
Personal data
Processing personal data
MRC, as part of UKRI, will need to collect some personal information to manage your Funding Service account and the registration of your funding applications.
We will handle personal data in line with UK data protection legislation and manage it securely. For more information, including how to exercise your rights, read our privacy notice.
Sensitive information
If you or a core team member needs to tell us something you wish to remain confidential, email humandiseasemodels@mrc.ukri.org
Include in the subject line: [the funding opportunity title; sensitive information; your Funding Service application number].
Typical examples of confidential information include:
- individual is unavailable until a certain date (for example due to parental leave)
- declaration of interest
- additional information about eligibility to apply that would not be appropriately shared in the ‘Applicant and team capability’ section
- conflict of interest for UKRI to consider in reviewer or panel participant selection
For information about how UKRI handles personal data, read UKRI’s privacy notice.
Institutional matched funding
There is no requirement for matched funding from the institutions hosting the project lead, project co-leads or other staff employed on the application, beyond the standard 20% FEC. Expert reviewers and panels assessing UKRI funding applications must not consider levels of institutional matched funding as a factor on which to base recommendations. Direct and in-kind contributions from third party project partners are encouraged.
This policy does not remove the need for support from host organisations who must provide the necessary research environment and infrastructure for award-specific activities funded by UKRI. For example, research facilities, training and development of staff.
Publication of outcomes
MRC, as part of UKRI, will publish the outcomes of this funding opportunity at Board and panel outcomes – MRC.
If your application is successful, we will publish some personal information on the UKRI Gateway to Research.
Summary
Word limit: 550
In plain English, provide a summary of your application.
We usually make this summary publicly available on external-facing websites, therefore do not include any confidential or sensitive information. Make it suitable for a variety of readers, for example:
- opinion-formers
- policymakers
- the public
- the wider research community
Guidance for writing a summary
Clearly describe your proposed work in terms of:
- context
- the challenge the project addresses
- aims and objectives
- potential applications and benefits
Core team
List the key members of your team and assign them roles from the following:
- project lead (PL)
- project co-lead (UK) (PcL)
- project co-lead (international) (PcL (I))
- specialists
- grant manager
- professional enabling staff
- research and innovation associate
- technician
- visiting researcher
- researcher co-lead (RcL)
Only list one individual as project lead. This should be the individual who will act as the grant holder with responsibilities to MRC at the start of the Hub award. If you include more than one project lead your application will fail at the checking stage.
List other leadership team members as project co-lead or international project co-lead.
All host organisations must be represented by an eligible co-lead.
The leadership team members’ application roles should not imply relative status or influence the leadership model which is for the applicants to propose.
We encourage inclusion of senior professional enabling staff such as a chief operating officer.
UKRI has introduced a new addition to the ‘Specialist’ role type. Public contributors such as people with lived experience can now be added to an application.
Find out more about UKRI’s core team roles in funding applications.
Application questions
Approach
Word limit: 5,500
How are you going to deliver your proposed work?
What the assessors are looking for in your response
Explain how you have designed your approach so that it:
- is effective and appropriate to achieve your objectives
- is feasible, and comprehensively identifies any risks to delivery and how they will be managed
- uses a clearly written and transparent methodology (if applicable)
- summarises the previous work and describes how this will be built upon and progressed (if applicable)
- will maximise translation of outputs into outcomes and impacts
- describes how your, and if applicable your team’s, research environment (in terms of the place and relevance to the project) will contribute to the success of the work
- will build EDI considerations into the formation, operation and governance of the hub, including how these will be operationalised
- outlines future plans for sustaining the Hub beyond this application
Within the Approach section we also expect you to:
- explain and justify how you will approach diversity and inclusion in the study population and follow the MRC embedding diversity in research design policy (if applicable)
- show how you will use male and female animals or tissues and cells from female and male donors (if applicable). If you are not proposing to do this, justify why
- explain and justify the inclusion of public partnerships (if applicable) and the added value these offer
References may be included within this section.
You may demonstrate elements of your responses in visual form if relevant. Further details are provided in the Funding Service.
Translation and knowledge transfer and exchange
Word limit: 1,000
What is your approach to translational research and knowledge transfer and exchange?
What the assessors are looking for in your response
Explain your approach, including:
- how your translational research approach will be developed within the hub or with partners
- how you will maximise the potential benefit of research undertaken in the hub to the research community, wider society and economy
- how you plan to maximise engagement with relevant stakeholders (academia, industry, charities, policy makers) to ensure the appropriate sharing of knowledge and expertise
Intellectual property rights (IPR)
Word limit: 700
Provide a brief description of the intellectual assets underpinning the proposed work (if any).
What the assessors are looking for in your response
Completing this section is compulsory for all applications, even if your project is not expected to generate new intellectual property (IP). Failure to provide this information will result in your application being rejected.
Where applicable, describe your future IP management plans to:
- manage the outputs of the project, including any intellectual assets and intellectual property
- have freedom to operate
- protect the foreground IP or market position
- disseminate and communicate the outputs of your project
The assessors are looking for you to outline where IP and freedom to operate considerations will need to be accounted for (for example where licenses will need to be obtained).
Note that, at the time of application, or during any subsequent grant, UKRI would not anticipate any business to have exclusive rights to the assets and IP arising from the funded project.
The assessors will judge whether there is an appropriate intellectual property strategy in place to facilitate downstream development, clinical uptake or commercialisation.
Environmental sustainability
Word limit: 500
How will you approach environmental sustainability?
What the assessors are looking for in your response
Explain how you will:
- promote environmental sustainability with the hub’s research practices
- adopt relevant standards
- align your environmental sustainability strategy with host research organisation sustainability plans and policies
Data management and sharing
Word limit:1,500
How will you manage and share data collected or acquired through the proposed research?
What the assessors are looking for in your response
Provide a data management plan which should clearly detail how you will comply with MRC’s published data management and sharing policies, which includes detailed guidance notes.
Provide your response in the text box following the headings in the MRC data management plan template. You are not required to upload the document to your application.
The length of your plan will vary depending on the type of study being undertaken, as follows:
- population cohorts, longitudinal studies, genetic, omics and imaging data, biobanks, and other collections that are potentially a rich resource for the wider research community: maximum of 1,500 words
- all other research, less complex, the plan may be as short as 500 words
Leadership, operations and decision-making
Word limit: 1,500
How will you approach running the hub?
What the assessors are looking for in your response
Explain how the proposed hub:
- will be effectively and inclusively managed including describing a leadership team with clear roles and responsibilities
- will approach decision-making and agility in response to new scientific developments, and the processes and criteria to take decisions on future research directions
- has clear governance plans to successfully function as a research entity, and coordinate activities across multiple sites (if applicable)
How the hub will access the appropriate services, facilities, infrastructure, or equipment to deliver the proposed research should be described in the ‘Your host research organisation support’ section.
You may demonstrate elements of your responses in visual form if relevant. Further details are provided in the Funding Service.
Applicant and team capability to deliver
Word limit: 2,000
Why are you the right leadership team to successfully deliver the proposed work?
What the assessors are looking for in your response
Evidence of how your team, have:
- the relevant experience (appropriate to career stage) to deliver the proposed work
- the right balance of skills and expertise to cover the proposed work
- the appropriate leadership and management skills to deliver the work and your approach to develop others
- contributed to developing a positive research environment and wider community
You may demonstrate elements of your responses in visual form if relevant. Further details are provided in the Funding Service.
The word count for this section is 2,000 words, 1,500 words to be used for Résumé for Research and Innovation (R4RI) modules (including references) and, if necessary, a further 500 words for Additions.
Use the R4RI format to showcase the range of relevant skills you and, if relevant, your team (project and project co-leads, researchers, technicians, specialists, partners and so on) have and how this will help deliver the proposed work. You can include individuals’ specific achievements but only choose past contributions that best evidence their ability to deliver this work.
Complete this section using the R4RI module headings listed. Use each heading once and include a response for the whole team, see the UKRI guidance on R4RI. You should provide an integrated view of the skills and collective value of the team as a whole as they relate to the proposed challenge. You should consider how to balance your answer, and emphasise where appropriate the following key skills each team member brings in relation to your proposed hub, rather than listing the skills of each individual:
- contributions to the generation of new ideas, tools, methodologies, or knowledge
- the development of others and maintenance of effective working relationships
- contributions to the wider research and innovation community
- contributions to broader research or innovation users and audiences and towards wider societal benefit
Additions
Provide any further details relevant to your application. This section is optional and can be up to 500 words. You should not use it to describe additional skills, experiences, or outputs, but you can use it to describe any factors that provide context for the rest of your R4RI (for example, details of career breaks if you wish to disclose them).
You should complete this as a narrative. Do not format it like a CV.
References may be included within this section.
ORCID iD
Within the R4RI format, team members should include their ORCID iD as part of the ‘short role descriptor’.
The roles in funding applications policy has descriptions of the different project roles.
Research organisation support
Word limit: 2,500
How will your research organisation(s) support the planned Hub?
What the assessors are looking for in your response
We are looking for strong host support and capability to deliver, evidenced through a statement from an individual with oversight of the organisations research strategy, vice-chancellor research or equivalent.
An outline of the support offered from the research organisation to the Hub and description of how the research organisation will help the Hub meet our expectations.
The statement should include:
- name and position of all contributors to the statement
- how the Hub aligns with host organisation strategies (research, research culture, training, sustainability)
- the support and facilities you will offer the Hub
- how you will operate the Hub and help it address its challenge
- how the Hub will be governed within your organisation
Within the research organisation support section, we also expect you to explain how your support will contribute to a collaborative and stimulating multi or interdisciplinary research environment.
Project partners
Add details about any project partners contributions. If there are no project partners, you can indicate this on the Funding Service.
A project partner is a collaborating person or organisation who will have an integral role in your proposed research. This may include direct contributions for example cash, donated equipment and resources, or staff seconded to the project, or indirect and in-kind contributions for example use of project partner’s equipment, datasets, or facilities. Project partners may be in industry, academia, third sector or government organisations in the UK or overseas, including partners based in the EU.
A project partner is not anyone in your core team or anyone from your organisation or any of the other organisations represented by core team members.
Add the following project partner details:
- the organisation name (searchable via a drop-down list or enter the organisation’s details manually, as applicable)
- the project partner contact name and email address
- the type of contribution (direct or in-direct) and its monetary value
If a detail is entered incorrectly and you have saved the entry, remove the specific project partner record and re-add it with the correct information.
If there are specific circumstances where project partners do require funding for minor costs such as travel and subsistence, these project partner costs should be claimed and justified within the resources and costs section of your application.
Important information
If you are adding a project partner to this section, you must ensure they provide you with a letter or email of support and you upload it to ‘Project partners: letters or emails of support’.
If your project partners are from industry or a company, you must also complete the ‘Industry Collaboration Framework (ICF)’ section.
Project partners responsible for carrying out animal work
If the project partner is responsible for conducting animal work or providing animals or animal tissue samples, you must ensure that you complete and upload the appropriate forms under the sections ‘Research involving the use of animals’ and ‘Conducting research with animals overseas’ (if applicable).
For audit purposes, UKRI requires formal collaboration agreements to be put in place if an award is made.
Project partners: letters (or emails) of support
Word limit: 10
Upload a single PDF containing the letters or emails of support from each partner you named in the ‘Project partners’ section. These should be uploaded in English or Welsh only.
What the assessors are looking for in your response
If you do not have any project partners, you will be able to indicate this in the Funding Service.
What supporting statements we are looking for
We are looking for you to provide letters or emails of support from all your identified project partners.
What we are not looking for
We don’t want any other letters (or emails) of support, from people who are not your identified project partners, such as those simply expressing general support for your project. If these are included by you, they will be ignored by us and will not be used in the assessment process.
Important information
You should only provide letters or emails of support from people you have identified in the project partner section of your application, who will have an integral role in your proposed research.
What each project partner letter or email of support must include
Each project partner letter or email you provide should:
- include the name of the project partner organisation and contact information
- explain the project partners’ commitment to the project
- explain the value, relevance, and possible benefits of the proposed work, to them
- describe any additional value they will bring to the project
- not exceed two sides of A4 per project partner
Project partner letters and emails of support are not required to be on headed paper or include handwritten signatures (electronic signatures are acceptable).
The Funding Service will provide document upload details when you apply.
Project partners from industry or a company
Industry or company project partners are required to download and complete the industry or company letter of support template. You must also complete the ‘Industry Collaboration Framework (ICF)’ section. Find out more about ICF.
Project partners responsible for recruiting research participants or providing human tissue or samples
If the project partner is responsible for the recruitment of people as research participants or providing human tissue their letter or email of support should include:
- agreement that the project partner will recruit the participants or provide tissue
- confirmation that what is being supplied is suitable for the proposed work
- confirmation that the quantity of tissue being supplied is suitable, but not excessive for achieving meaningful results (if applicable)
Agreement with your project partners
Ensure you have prior agreement from project partners so that, if you are offered funding, they will support your project as indicated in the ‘Project partners’ section.
For audit purposes, UKRI requires formal collaboration agreements to be put in place if an award is made.
Industry Collaboration Framework (ICF)
Word limit: 1,500
Does your application include collaboration with industry or company project partners?
What the assessors are looking for in your response
The assessors are looking for you to confirm if your proposed work involves collaboration with an industry or company project partner. If it does, you will need to follow the MRC industry collaboration framework (ICF).
By ‘industry or company’ we mean an enterprise that puts or has intention to put goods or services on a market.
For guidance to assist your decision if your proposed work requires you to follow ICF, you should explore the ICF decision tree and find out more about ICF which includes:
- collaboration agreements
- definitions of basic or applied research
- internationally based companies
- subsidy control
- intellectual property (IP) arrangements
- fully flexible and gated contributions
- the ICF assessment criteria
Enter ‘Yes’ in the text box if you have industry or company project partners and you are likely to follow ICF. You should also confirm your answers to the ICF questions one to nine in the text box for each ICF project partner.
Contact us if you are unsure if your application should follow ICF.
In addition to the project partner information completed in the previous section, the assessors are looking for information relating to the nature, goals and conditions of the collaboration and any restrictions or rights to the project results that could be claimed by the industry or company project partner.
Confirm your answers to the ICF questions in the text box, repeat this process for each ICF project partner.
- Name the industry or company project partner considered under ICF.
- Indicate whether your application is basic research or applied research.
- Explain why, in the absence of the requested UKRI funding, the collaboration and the planned research could not be undertaken.
- State whether your application is under the category of fully flexible contribution or gated contribution (based on the IP sharing arrangements with the industry or company partner).
- Outline the pre-existing IP (‘background IP’) that each partner, including the academic partner, will bring to the collaborative research project and the terms under which partners may access these assets.
- Outline the IP that is expected to be developed during the collaborative research project (‘foreground IP’) and briefly outline how it will be managed, including:
- who will own this IP
- what rights industry or company partners will have to use academically-generated foreground IP during and after the research project, for internal research and development or for commercial purposes
- any rights of the academic partner to commercialise the foreground IP, including foreground IP generated by industry or company partners
- Outline any restrictions to dissemination of the project results, including the rights of the industry or company partner to:
- review, approve or delay publications (including the time period associated with such rights)
- request or require the removal of any information
- Declare any conflicts of interest held by the applicants in relation to the industry or company project partners and describe how they will be managed.
- Justify collaborating with an overseas industry or company under ICF (if applicable).
Failure to provide the information requested for industry or company partners under ICF could result in your application being rejected.
You are recommended to discuss the goals and conditions of any collaboration with an industry or company with your technology transfer or contracts office before applying.
For audit purposes, UKRI requires formal collaboration agreements to be put in place if an award is made. You must provide us with a copy of the collaboration agreement, signed by all partners, before an ICF award starts.
If this does not apply to your proposed work, you will be able to indicate this in the Funding Service.
Trusted Research and Innovation (TR&I)
Word limit: 100
Does your proposed work relate to UKRI’s Trusted Research and Innovation principles?
What the assessors are looking for in your response
Demonstrate how your proposed work relates to UKRI’s Trusted Research and Innovation principles including:
- list any dual-use (both military and non-military) applications to your research
- if this project is relevant to one or more of the 17 areas of the UK National Security and Investment (NSI) Act, please list the area(s)
- please read the academic export control guidance and confirm if an export control license is required for this project and the status of any application(s)
- if your project involves any items or substances on the UK strategic export control list, please list these
We may ask you to provide additional TR&I information later, in line with UKRI TR&I Principles and funding terms and conditions (RGC 2.6.2, 2.7.1 and 2.7.2).
International collaboration
Word limit: 100
Does the proposed work involve any international collaboration or engagement?
What the assessors are looking for in your response
Provide details about your expected international collaboration or engagement, including:
- a list of the countries your international project co-leads, project partners, visiting researchers, or other collaborators are based in
- details of any subcontractors or service providers
If your proposed work does not involve international collaboration or engagement, you will be able to indicate this in the Funding Service.
Equipment
Word count: 500
Do you want to request any mid-range or large equipment?
What the assessors are looking for in your response
If you want to request mid-range or large equipment critical to establish platforms or facilities at the Hub:
- list the equipment items
- include an estimated cost for each
- provide the percentage full economic cost to be requested
- justify why the equipment is required and how it will be used
Mid-range equipment is a single item costing over £138,000 (£115,000 excluding VAT).
If you do not want to request any mid-range or large equipment you will be able to indicate this in the Funding Service.
Ethics and responsible research and innovation (RRI)
Word limit: 500
What are the ethical or RRI implications and issues relating to the proposed work? If you do not think that the proposed work raises any ethical or RRI issues, explain why.
What the assessors are looking for in your response
Demonstrate that you have identified and evaluated:
- the relevant ethical and RRI considerations, including both the research or topic area itself and the design and delivery of the project
- the wider implications of the proposed work, and how you will maximise the positive societal, environmental, and economic benefits arising from the project, whilst minimising unintended negative impacts, such as research misuse or accidental harm
- how you will manage these considerations throughout the lifecycle of the project
Consider the MRC guidance on ethics and approvals.
You may demonstrate elements of your responses in visual form if relevant. Further details are provided in the Funding Service.
Please refer to the UKRI position statement on funding ethical research and Responsible innovation for more information around our expectations on ethical and responsible research and innovation.
Genetic and biological risk
Word limit: 700
Does your proposed research involve any genetic or biological risk?
What the assessors are looking for in your response
In respect of animals, plants or microbes, are you proposing to:
- use genetic modification as an experimental tool, like studying gene function in a genetically modified organism
- release genetically modified organisms
- ultimately develop commercial and industrial genetically modified outcomes
If yes, provide the name of any required approving body and state if approval is already in place. If it is not, provide an indicative timeframe for obtaining the required approval.
Identify the organism or organisms as a plant, animal or microbe and specify the species and which of the three categories the research relates to.
Identify the genetic and biological risks resulting from the proposed research, their implications, and any mitigation you plan on taking. Assessors will want to know you have considered the risks and their implications to justify that any identified risks do not outweigh any benefits of the proposed research.
If this does not apply to your proposed work, you will be able to indicate this in the Funding Service.
Research involving the use of animals
Word limit: 10
Does your proposed research involve the use of vertebrate animals or other organisms covered by the Animals Scientific Procedures Act?
What the assessors are looking for in your response
If you are proposing research that requires using animals, download and complete the Research involving the use of animals template (DOCX, 52.5KB), which contains all the questions relating to research using vertebrate animals or other Animals (Scientific Procedures) Act 1986 regulated organisms.
When a project partner will be responsible
If a project partner will conduct animal work for the proposed research, or will provide animals or animal tissue, you must:
- upload a letter of support under the ‘Project partners: letters (or emails) of support’ section
- complete and upload the required template in this section
- complete and upload the template in the ‘Conducting research with animals overseas’ section (if applicable)
Save it as a PDF. The Funding Service will provide document upload details when you apply.
If this does not apply to your proposed work, you will be able to indicate this in the Funding Service.
Conducting research with animals overseas
Word limit: 700
Will any of the proposed animal research be conducted overseas?
What the assessors are looking for in your response
If you are proposing to conduct overseas research, it must be conducted in accordance with welfare standards consistent with those in the UK, as in Responsibility in the use of animals in bioscience research. Ensure all named applicants in the UK and overseas are aware of this requirement.
If your application proposes animal research to be conducted overseas, you must provide a statement in the text box. Depending on the species involved, you may also need to upload a completed template for each species listed.
Statement
Provide a statement to confirm that:
- all named applicants are aware of the requirements and have agreed to abide by them
- this overseas research will be conducted in accordance with welfare standards consistent with the principles of UK legislation
- the expectation set out in Responsibility in the use of animals in bioscience research will be applied and maintained
- appropriate national and institutional approvals are in place
Templates
Overseas studies proposing to use non-human primates, cats, dogs, equines or pigs will be assessed during NC3Rs review of research applications. Provide the required information by completing the template from the question ‘Research involving the use of animals’.
For studies involving other species, such as:
- rodents
- rabbits
- sheep
- goats
- pigs
- cattle
- xenopus laevis and xenopus tropicalis
- zebrafish
Select, download, and complete the relevant Word checklist or checklists by exploring NC3Rs checklist for the use of animals overseas.
Save your completed template as a PDF and upload to the Funding Service. If you use more than one checklist template, save it as a single PDF.
The Funding Service will provide document upload details when you apply.
If conducting research with animals overseas does not apply to your proposed work, you will be able to indicate this in the Funding Service.
Research involving human participation
Word limit: 700
Will the project involve the use of human subjects or their personal information?
What the assessors are looking for in your response
If you are proposing research that requires the involvement of human subjects, provide the name of any required approving body and whether approval is already in place.
Justify the number and the diversity of the participants involved, as well as any procedures.
Provide details of any areas of substantial or moderate severity of impact.
If this does not apply to your proposed work, you will be able to indicate this in the Funding Service.
Research involving human tissues or biological samples
Word limit: 700
Does your proposed research involve the use of human tissues, or biological samples?
What the assessors are looking for in your response
If you are proposing work that involves human tissues or biological samples, provide the name of any required approving body and whether approval is already in place.
Justify the use of human tissue or biological samples specifying the nature and quantity of the material to be used and its source.
If this does not apply to your proposed work, you will be able to indicate this in the Funding Service.
Resources and cost justification
Word limit: 2,000
What will you need to deliver your proposed work and how much will it cost?
What the assessors are looking for in your response
Justify the application’s more costly resources, in particular:
- hub and project staff
- significant travel for field work or collaboration (but not regular travel between collaborating organisations or to conferences)
- any equipment that will cost more than £25,000, including routine equipment and mid-range or large equipment
- any consumables beyond typical requirements, or that are required in exceptional quantities
- all facilities and infrastructure costs
- all resources that have been costed as ‘Exceptions’
- initiatives to improve environmental sustainability
- preserving, long term storage, or sharing of data, including open science
- activities to increase impact, for public partnerships and related activities, including public engagement and involvement and payments to public contributors, knowledge transfer and exchange or to support responsible innovation
You can request costs associated with reasonable adjustments where they increase as a direct result of working on the project. For further information see Disability and accessibility support for UKRI applicants and grant holders.
Assessors are not looking for detailed costs or a line-by-line breakdown of all project resources. Overall, they want you to demonstrate how the resources you anticipate needing for your proposed work:
- are comprehensive, appropriate, and justified
- represent the optimal use of resources to achieve the intended outcomes
- maximise potential outcomes and impacts
Clinical research using NHS resources
Word limit: 250
Are you applying to do clinical research in the UK?
What the assessors are looking for in your response
Researchers applying to do clinical research in the NHS, public health or social care usually need to complete a Schedule of Events Cost Attribution Tool (SoECAT).
We request the SoECAT because we want to know that you have taken the appropriate steps to request National institute for Health and Care Research (NIHR) support and for the full costs of your research to be attributed, calculated and paid.
We want to see the expected total resources required for your project to consider if these are appropriate.
Enter ‘Yes’ and complete and upload a SoECAT if you are applying for clinical research and:
- you will carry out your research in the UK
- your research will use NHS resources
- the research requires approval by Health Research Authority (England) or its equivalents in Northern Ireland, Scotland or Wales
- you will need support from the NIHR Research Delivery Network, this may include studies in a social care or public health setting
It is important to complete a SoECAT to be eligible for NIHR support. You must complete a SoECAT even if you don’t think your clinical research will involve excess treatment costs (ETCs).
See MRC guidance on who needs to complete a SoECAT.
How to complete a SoECAT
SoECAT guidance can be found on the NIHR website.
These are the steps you need to take:
- Contact an attributing the costs of health and social care Research & Development (AcoRD) specialist as early as possible in the application process.
- Complete an online SoECAT. Excel versions of the form have been discontinued. If you don’t have an account for NIHR’s Central Portfolio Management System (CPMS) you will need create and activate one. See the NIHR user guide for instructions.
- Request authorisation of your SoECAT.
- Once authorised extract the ‘study information’ and the ‘summary’ page from the ‘Funder Export’, combine them as a single PDF and upload it to your application.
Applications that require a SoECAT but have not uploaded the SoECAT funder export study information and summary may be rejected.
Ensure the AcoRD specialists name and date are included within the uploaded summary page. The SoECAT is invalid without this information.
Contact us if you have questions about the UKRI aspects of this process.
If this does not apply to your proposed work, you will be able to indicate this in the Funding Service.
