Funding opportunity

Funding opportunity: Invite only: Precision prevention: biological mechanisms of response variation

Start application

Apply for funding to investigate why biomedical prevention interventions work differently across people. Projects must generate mechanistic evidence in humans by testing biomedical experimental interventions or challenges in pre-disease or early disease states, providing insight into how to improve the targeting and effectiveness of precision prevention strategies.

Your project must:

  • include an experimental intervention or challenge in humans
  • focus on a mechanistic hypothesis

The full economic cost (FEC) of your project can be up to £5 million over a duration of up to five years. MRC will fund 80% of your project’s full economic cost.

You must have submitted a mandatory expression of interest (EOI) and be invited to submit a full application.

Who can apply

This opportunity is open to organisations with standard eligibility. Check if your organisation is eligible.

You can only apply for this funding opportunity if we have invited you to do so following a successful expression of interest.

Who is eligible to apply

To be eligible to apply for this funding opportunity you must:

  • be employed by an eligible research organisation
  • show that you will direct the project and be actively engaged in the work
  • be part of a team invited to apply after submitting an expression of interest

For applicants who do not have a contract of employment for the duration of the proposed project, by submitting an application the research organisation is confirming, if it is successful:

  • contracts will be extended beyond the end date of the project
  • all necessary support for the project and the applicants will be provided, including mentorship and career development for early career researchers

A research organisation may lead or partner on more than one application and applications may comprise more than one research organisation.
Individuals may be project lead on only one application. However, individuals can act as project co-leads on any number of applications.

Who is not eligible to apply

If you are employed by these organisations you cannot apply as project lead or project co-lead, but can participate as project partners on an application led by an eligible UK organisation:

  • businesses
  • charity and third sector organisations

International researchers

As MRC is a lead funder for this funding opportunity, international researchers can apply as ‘project co-lead (international)’.

Project co-leads (international) make a major intellectual contribution to the design or conduct of the project. Their contribution and added value to the research collaboration should be clearly explained and justified in the application, using the appropriate application sections, such as ‘Applicant and team capability to deliver’.

Read the UK Research and Innovation (UKRI) project co-lead (international) eligibility policy for more details. Please contact us if you are uncertain about eligibility.

You should include all other international collaborators (or UK partners not based at approved organisations) as project partners.

Equality, diversity and inclusion

We are committed to achieving equality of opportunity for all funding applicants. We encourage applications from a diverse range of researchers.

We support people to work in a way that suits their personal circumstances. This includes:

  • career breaks
  • support for people with caring responsibilities
  • flexible working
  • alternative working patterns

UKRI can offer disability and accessibility support for UKRI applicants and grant holders during the application and assessment process.

What we're looking for

Demand management

Demand management is not being applied to this funding opportunity.

Scope

As the UK population grows and ages, increasing rates of ill health and declining healthy life expectancy are contributing to a worrying trajectory for health outcomes. The shift to prevention from treatment as part of the 10-year NHS health plan for England has the potential to reduce the burden of multiple long-term conditions and chronic diseases, support an ageing population, tackle health inequalities, lower associated NHS costs, boost productivity and drive economic growth.

Some effective prevention interventions already exist, but their impact is often limited by substantial variation in how individuals and populations respond. Heterogeneity is commonly observed in response, risk reduction, adverse effects, and clinical outcomes associated with biomedical interventions. The biological mechanistic pathways underpinning this variation are poorly understood.

Current approaches typically rely on average effects across diverse populations, leading to suboptimal benefit, unnecessary treatment, and persistent health inequalities. This funding opportunity aims to support interventional studies in humans to validate a mechanistic hypothesis and directly interrogate the biological mechanisms governing the transition from health to early disease and the mechanisms underlying variation in response to biomedical prevention interventions.

By deploying experimental challenges, interventions or controlled perturbations, studies can test biological mechanisms, with measurable outcomes providing evidence of the pathways involved, rather than inferring them from observational data. These mechanistic insights then inform how prevention interventions could be better targeted, timed, and delivered across different populations. These findings should contribute to an iterative feedback loop of mechanistic insight and re-testing that enables progressively more precise and effective prevention strategies.

Studies may address the heterogeneity of response of existing validated prevention interventions or investigate biological mechanisms that could support the future development of novel precision prevention interventions. In all cases, relevant, validated biological readouts must be measured to test the proposed mechanistic hypothesis. Exploratory biomarker studies are not eligible for funding.

Successful projects should address a clearly articulated gap in understanding the mechanisms underlying variation in response to preventive interventions or the biological mechanisms governing the transition from health to early disease. This should have a clear pathway to informing the targeting, timing, or optimisation of precision prevention approaches. Projects should demonstrate how these insights could enhance the effectiveness, efficiency, and equity of prevention, including by identifying opportunities to tailor interventions to those (high risk) people and populations most likely to benefit.

Project themes could include a combination of:

  • improving mechanistic understanding of how interventions modify biological pathways across different population groups, enabling more personalised and equitable prevention approaches and avoiding harm
  • generating mechanistic insights into early disease pathways that can enable the future development and tailoring of novel precision prevention approaches and support the stratification of populations
  • use of current treatment interventions as mechanistic tools to understand pathways that influence responsiveness to prevention interventions and inform stratified prevention approaches
  • validating surrogate endpoints that reflect biological mechanisms underlying heterogeneity in response to prevention interventions and track the transition between health and disease. This should not be the primary focus of the application

This list is not exhaustive.

What your application must include

Your application must involve an experimental investigation in humans at its core, which has been designed to validate a mechanistic hypothesis. Projects must focus on the pre-disease state, early stage or emergence of disease. This should include a biomedical intervention or challenge, with an established safety profile, such as pharmacological or immunological.

We particularly welcome applications that address gaps in our understanding of biological mechanisms in multiple long-term conditions and metabolic disease and, where relevant, in underrepresented populations.

Activities we do not support

The activities that are ineligible for support are:

  • characterisation or phenotyping work aiming to elucidate disease aetiology, where this is the main aim and without an experimental challenge or prevention intervention context
  • experimental intervention or challenge in animals, using clinical assets to explore prevention and disease mechanisms and pathways
  • biomarker discovery projects
  • projects where the primary mechanistic question is directed at managing established disease rather than preventing its onset (tertiary prevention)
  • pre-clinical model development and validation

These activities are supported through the following MRC applicant-led funding opportunities:

The following activities are also ineligible for support through this funding opportunity:

Learn about MRC’s remit, programmes and priority areas.

Please see the ‘Additional information’ section for a video on this funding opportunity and answers to frequently asked questions.

Milestones

Milestones allow us to mitigate risk and support potentially high-risk, innovative projects.

Experimental medicine awards will typically have at least two milestones with defined success criteria that reflect timely progression points and allow mechanistic hypotheses to be laid out and assessed as the project moves forward.

As part of the invited full application stage, your milestones should also provide a realistic indication of timelines for key steps, such as regulatory steps, study team recruitment, participant recruitment, study completion and data analysis.

Milestone success criteria should be SMART (specific, measurable, achievable, relevant and timely) and detail any robust go or no-go criteria. For all projects, it is advisable to structure the project so that the critical questions are addressed as early as possible in the plan.

Duration

Projects may last up to five years. You should clearly justify the proposed duration in relation to the scope, complexity and objectives of the work.

Funding available

The FEC of your project can be up to £5 million.

MRC will fund 80% of the FEC and 100% of permitted exceptions.

The maximum MRC contribution, including any identified exceptions funded at 100%, is £4 million.

Find out more about full economic costing.

What we will fund

You can request funding for costs such as:

  • a contribution to the salary of the project lead and co-leads
  • support for other posts such as research and technical staff
  • research consumables
  • equipment
  • travel costs
  • data preservation, data sharing and dissemination costs
  • estates and indirect costs
  • public partnerships and related activities, including payments to public contributors

You can also request costs for work to be undertaken at international organisations by international project co-leads. We will fund 100% of the eligible costs.

The total of such costs requested for international applicants from high income countries (those not on the OECD DAC list of ODA recipients), India and China, must not exceed 30% of the total resources requested.

There is no cap on costs requested for international applicants from development assistance countries (DAC).

For more information on international costs and what we will and will not fund see costs we fund and the Collaborate with Researchers in Norway guidance.

What we will not fund

We will not fund:

  • research involving randomised trials of clinical treatments
  • costs for PhD studentships
  • publication costs
  • funding to use as a ‘bridge’ between grants

Project partner

A project partner is a collaborating organisation in the UK or overseas, including partners based in the EU, who will have an integral role in the proposed research. You may include project partners that will support your research project through cash or in-kind contributions, such as:

  • staff time
  • access to equipment
  • sites or facilities
  • the provision of data
  • software or materials
  • recruitment of people as research participants
  • providing samples, such as human tissue, for the project

Each project partner must provide a statement of support. If your application involves industry partners, they must provide additional information if the relationship falls within the industry collaboration framework.

Find out more about subcontractors and dual roles.

Who cannot be included as a project partner

Any individual included in your application core team cannot also be a project partner.

Any organisation that employs a member of the application core team cannot be a project partner organisation. This includes other departments within the same organisation.

If you are collaborating with someone in your organisation, consider including them in the core team as project co-lead, or specialist. They cannot be a project partner.

Human participation in research

If you are applying to do research in the NHS, public health or social care you usually need to complete a Schedule of Events Cost Attribution Tool (SoECAT). We are looking for evidence you have taken the appropriate steps and for the full costs of your research to be appropriately attributed.

It is important to complete a SoECAT to be eligible for support from the National Institute for Health Research (NIHR) Research Delivery Network. You must complete a SoECAT even if you don’t think your research will involve excess treatment costs.

See MRC guidance on who needs to complete a SoECAT.

SoECAT guidance can be found on the NIHR website.

These are the steps you need to take:

  1. Contact an attributing the costs of health and social care Research and Development (AcoRD) specialist as early as possible in the application process.
  2. Complete an online SoECAT. If you do not have an account for NIHR’s Central Portfolio Management System you will need to create and activate one.
  3. Request authorisation of your SoECAT.
  4. When you have authorisation, include the ‘funder export’ Excel document from your SoECAT as part of your application in the Human participation in health-related research section.

Contact us about any issues including a SoECAT or AcoRD specialist feedback in your application, such as:

  • your proposed research involves human participation and the NHS, but you don’t think you need a SoECAT, explain why not when you contact us
  • your proposed research involves human participation in health and social care (not NHS), and you think you need a SoECAT

Find contacts in the ‘Contact details’ section.

Supporting skills and talent

We encourage you to follow the principles of the Concordat to Support the Career Development of Researchers and the Technician Commitment.

Trusted Research and Innovation (TR&I)

UK Research and Innovation (UKRI) is committed in ensuring that effective international collaboration in research and innovation takes place with integrity and within strong ethical frameworks. Trusted Research and Innovation (TR&I) is a UKRI work programme designed to help protect all those working in our thriving and collaborative international sector by enabling partnerships to be as open as possible, and as secure as necessary. Our TR&I Principles set out UKRI’s expectations of organisations funded by UKRI in relation to due diligence for international collaboration.

As such, applicants for UKRI funding may be asked to demonstrate how their proposed projects will comply with our approach and expectation towards TR&I, identifying potential risks and the relevant controls you will put in place to help proportionately reduce these risks.

See further guidance and information about TR&I, including where applicants can find additional support.

How to apply

We are running this funding opportunity on the new UK Research and Innovation (UKRI) Funding Service so please ensure that your organisation is registered. You cannot apply on the Joint Electronic Submissions (Je-S) system.

The project lead is responsible for completing the application process on the Funding Service, but we expect all team members and project partners to contribute to the application.

Only the lead research organisation can submit an application to UKRI.

To apply

Select ‘Start application’ near the beginning of this Funding finder page.

  1. Confirm you are the project lead.
  2. Sign in or create a Funding Service account. To create an account, select your organisation, verify your email address, and set a password.
  3. Answer questions directly in the text boxes. You can save your answers and come back to complete them or work offline and return to copy and paste your answers. If we need you to upload a document, follow the upload instructions in the Funding Service. All questions and assessment criteria are listed in the How to apply section on this Funding finder page.
  4. Allow enough time to check your application in ‘read-only’ view before sending to your research office.
  5. Send the completed application to your research office for checking. They will return it to you if it needs editing.
  6. Your research office will submit the completed and checked application to UKRI.

Please be aware that research office and finance teams undertake checks on hosting arrangements and financial eligibility. The ultimate responsibility for ensuring compliance with all opportunity requirements lies with the applicant.

Where indicated, you can also demonstrate elements of your responses in visual form if relevant.

When including images, you must:

  • provide a descriptive caption or legend for each image immediately underneath it in the text box (this must be outside the image and counts towards your word limit)
  • insert each new image on a new line
  • use files smaller than 5MB and in JPEG, JPG, JPE, JFI, JIF, JFIF, PNG, GIF, BMP or WEBP formatImages should only be used to convey important visual information that cannot easily be put into words. The following are not permitted, and your application will be rejected if you include:
  • sentences or paragraphs of text
  • tables
  • excessive quantities of images

A few words are permitted where the image would lack clarity without the contextual words, such as a diagram, where text labels are required for an axis or graph column.

For more guidance on the Funding Service, see:

General use of hyperlinks

Applications should be self-contained. You should only use hyperlinks to link directly to reference information. You must not include links to web resources to extend your application. Assessors are not required to access links to conduct assessment or recommend a funding decision.

Generative artificial intelligence (AI)

Use of generative AI tools to prepare funding applications is permitted, however, caution should be applied.

For more information see our policy on the use of generative AI in application and assessment.

Deadline

MRC must receive your application by 5 November 2026 4:00pm UK time.

You will not be able to apply after this time.

Make sure you are aware of and follow any internal institutional deadlines.

Following the submission of your application to this funding opportunity, your application cannot be changed, and submitted applications will not be amended. If your application does not follow the guidance, it may be rejected.

Personal data

Processing personal data

MRC as part of UKRI, will need to collect some personal information to manage your Funding Service account and the registration of your funding applications.

We will handle personal data in line with UK data protection legislation and manage it securely. For more information, including how to exercise your rights, read our privacy notice.

Sensitive information

If you or a core team member need to tell us something you wish to remain confidential, email PPexpmed@mrc.ukri.org

Include in the subject line: [the funding opportunity title; sensitive information; your Funding Service application number].

Typical examples of confidential information include:

  • individual is unavailable until a certain date (for example due to parental leave)
  • declaration of interest
  • additional information about eligibility to apply that would not be appropriately shared in the ‘Applicant and team capability’ section
  • conflict of interest for UKRI to consider in reviewer or panel participant selection

For information about how UKRI handles personal data, read UKRI’s privacy notice.

Institutional matched funding

There is no requirement for matched funding from the institutions hosting the project lead, project co-leads or other staff employed on the application, beyond the standard 20% FEC. Expert reviewers and panels assessing UKRI funding applications must not consider levels of institutional matched funding as a factor on which to base recommendations. Direct and in-kind contributions from third party project partners are encouraged.

This policy does not remove the need for support from host organisations who must provide the necessary research environment and infrastructure for award-specific activities funded by UKRI. For example, research facilities, training and development of staff.

Publication of outcomes

If your application is successful, we will publish some personal information on the UKRI Gateway to Research.

Summary

Word limit: 550

In plain English, provide a summary we can use to identify the most suitable experts to assess your application.

We usually make this summary publicly available on external-facing websites, therefore do not include any confidential or sensitive information. Make it suitable for a variety of readers, for example:

  • opinion-formers
  • policymakers
  • the public
  • the wider research community

Guidance for writing a summary

Clearly describe your proposed work in terms of:

  • context
  • the challenge the project addresses
  • aims and objectives
  • potential applications and benefits

Core team

List the key members of your team and assign them roles from the following:

  • project lead (PL)
  • project co-lead (UK) (PcL)
  • project co-lead (international) (PcL (I))
  • specialist
  • grant manager
  • professional enabling staff
  • research and innovation associate
  • technician
  • visiting researcher
  • researcher co-lead (RcL)

Only list one individual as project lead. If you include more than one project lead your application will fail at the checking stage.

UKRI has introduced a new addition to the ‘Specialist’ role type. Public contributors such as people with lived experience can now be added to an application.

Find out more about UKRI’s core team roles in funding applications.

Application questions

Keywords

Word limit: 10

Provide up to five keywords that describe your application.

What the assessors are looking for in your response

Provide up to a maximum of five keywords including the health area, for example: mental health, engineering biology, environmental health, diagnosis, obesity, vaccine development.

Use commas or spaces to distinguish individual terms or phrases.

This is for administrative purposes to help with the initial application processing and will not affect the overall assessment or influence the outcome of your application.

Vision

Word limit: 1,100

What are you hoping to achieve with your proposed work?

What the assessors are looking for in your response

Explain how your proposed work:

  • aligns to the aims of the funding opportunity
  • is of excellent quality and importance within or beyond the field(s) or area(s)
  • has the potential to advance current understanding, or generate new knowledge, thinking or discovery in the context of precision prevention
  • is timely given current trends, context, and needs
  • impacts world-leading research, society, the economy, or the environment

Within the Vision section we also expect you to:

  • provide details of the current clinical challenge or knowledge gap
  • summarise the current state of understanding about the relevant mechanisms of disease
  • identify the current gap in mechanistic understanding
  • state the mechanistic hypothesis to be tested, which will generate mechanistic insights which would allow tailoring, targeting, and optimisation of existing prevention interventions or the development of new ones
  • identify the potential direct or indirect benefits and who the beneficiaries might be
  • identify potential improvements in human health, whether through contributing to preventing disease progression, relieving disease or disability burden, improving quality of life or providing benefit to the health service or health-related industry
  • if applicable, describe the route to patient benefit
  • explain if the results will be valuable for discovery science through ‘reverse translation’

References may be included within this section.

You may demonstrate elements of your responses in visual form if relevant. Further details are provided in the Funding Service.

Intervention

Word limit: 550

What is the planned biomedical intervention?

What the assessors are looking for in your response

Explain the planned intervention to be used in the proposed work, including:

  • the type of intervention, which must be biomedical such as for example, pharmacological or immunological
  • relevant background information, including its established safety profile and use in other mechanistic studies
  • if applicable, summarise the development history of the intervention
  • if applicable, provide details of any existing intellectual property (IP) associated with this intervention

References may be included throughout the intervention section.

You may demonstrate elements of your responses in visual form if relevant. Further details are provided in the Funding Service.

Approach

Word limit: 3,500

How are you going to deliver your proposed work?

What the assessors are looking for in your response

Within the Approach section we expect you to provide a detailed and comprehensive project plan, including timelines in the form of an embedded Gantt chart or similar, including:

  • the objectives of the proposed research in order of priority
  • the primary and secondary experimental outcomes and how they relate to the experimental objectives
  • how the proposed work packages will ensure the project objectives are achieved
  • your explanation of how your approach is effective and appropriate to achieve your objectives

Please ensure that the provided Gantt chart is legible and includes:

  • project tasks (these being short, achievable and measurable activities) with, where relevant, the party responsible for delivering the task and dependency relationships between tasks
  • at least two progression milestones (to include the project end goal), these being major specifically-timed decision points

Within the Approach section, we also expect you to provide details on the proposed methodology and experimental design, including:

  • the experiments you will undertake to probe the stated hypothesis
  • the data you will collect and how it will test the hypothesis
  • the proposed trial design and why this approach is appropriate to meet the study objectives

As part of your methodology, describe the nature of human participation in your proposed work, including:

  • the characteristics of the participants (such as age, disease) and the rationale for their selection
  • the specific population groups in relation to their diversity characteristics and the proposed analysis, following the MRC embedding diversity in research design policy
  • target and acceptable levels of participant recruitment across the project timeline
  • evidence of recruitment feasibility
  • the human participant recruitment strategy, including the steps that will be taken if patient recruitment does not reach the set targets
  • describe your approach to ethical and regulatory approvals and their status. Consider the MRC guidance on ethics and approvals
  • if applicable, provide details of how any limited tissue or cell work will inform the human-centric proposed work and provide the name of any required approving body and whether approval is already in place. For any research involving tissues and cells, you must show how you will use male and female donors. If you are not proposing to do this, a strong justification is required
  • if applicable, explain the inclusion of public and patient partnerships and the added value these offer

Demonstrate that your proposed approach is feasible, and comprehensively identify any risks to delivery and how they will be managed, including:

  • how likely the risks are to occur
  • what their impact would be on the success and deliverability of the project
  • your risk mitigation strategy, giving particular consideration to any potential safety risks and how these risks will be controlled
  • you may include a risk table to support your response

Describe how your, and if applicable your team’s, research environment (in terms of the place and relevance to the project) will contribute to the success of the work.

Demonstrate access to the appropriate services, facilities, infrastructure, or equipment to deliver the proposed work, including:

  • specialist equipment or infrastructure required to deliver the project objectives
  • proposed use of existing joint research facilities or clinical infrastructure, for example Experimental Cancer Medicine Centres, NIHR Biomedical Research Centres, NIHR Clinical Research Facilities, including patient cohorts
  • if not already in place, explain how you will ensure this infrastructure is accessible by the project start date
  • describe how the approach builds on existing scientific, technical and clinical expertise and clinical research infrastructure, the nature of existing partnerships and the value these add

Describe how you will maximise translation of outputs into outcomes and impacts through your plans for engagement, communication and dissemination with:

  • the research community
  • industry
  • patients and the public

We suggest you structure your response using the following headings, with approximate words limits for each:

  • project plan: 1,650 words
  • methodology and experimental design: 850 words
  • risk management: 400 words
  • infrastructure and equipment: 400 words
  • engagement, communication and dissemination: 200 words

References may be included throughout the approach section.

You may demonstrate elements of your responses in visual form if relevant. Further details are provided in the Funding Service.

You should detail any information regarding your statistical design in the ‘Reproducibility and statistical design’ section.

Reproducibility and statistical design

Word limit: 500

How will you ensure your proposed work is reliable, robust and reproducible?

What assessors are looking for in your response

Information about reproducibility and how you will ensure reliability and robustness of your proposed work, such as further details of statistical analyses, methodology and experimental design, not provided in your approach.

We expect you to seek professional statistical or other relevant advice in preparing your response, which should include, as appropriate:

  • sample and effect sizes
  • planned statistical analyses
  • models chosen (for example animal model, cell line)
  • potential sources of bias and how these will be mitigated during analysis
  • how your approach to addressing diversity is reflected in the experimental design and analyses

Refer to the MRC guidance for applicants, for further information, examples and online tools.

If your proposed work involves animals, and you provide information on animal sample sizes and statistical analyses here, you should not duplicate it in the ‘Animal involvement and “3Rs”’ section. Use the ‘Animal involvement and “3Rs”’ section to provide information on the rationale for using animals, choice of species, welfare and procedure severity.

You may demonstrate elements of your responses in visual form if relevant. Further details are provided in the Funding Service.

The length of your response will vary depending on the type of project, you may not need to use 500 words.

Project milestones

Word limit: 1,500

Provide details of your project milestones.

What the assessors are looking for in your response

Provide at least two key progression milestones that will:

  • delineate the proposed work into costed project phases with clear go or no-go decision points
  • establish success criteria with target and acceptable thresholds

Milestones are key points within the project lifecycle where progress is assessed before moving on to the next phase. While project tasks and work packages may run concurrently across different milestones, the milestones themselves must not overlap and must occur at distinct, sequential timepoints.

Milestones must be SMART (specific, measurable, achievable, relevant, and time-framed). They should:

  • detail robust go or no-go criteria (failure to meet these will result in early termination of the project)
  • be structured so that critical questions are addressed as early as possible in the plan

Success criteria should be based on project outputs that must be achieved at that point, to justify continuing the work. Success criteria should align to project aims and objectives. For the final milestone: success criteria should reflect what would constitute success for the funded aspect of your project.

For each success criterion, specify:

  • a quantified target value you aim to achieve
  • a quantified acceptable value, which, if achieved, would still support project progression

A brief justification should be provided for the criteria and values selected, explaining why they are suitable for assessing progress at this point in the project. Note that target and acceptable values must be achieved at the same timepoint and that milestones must be sequential.

Do not include project management meetings or other process-related tasks as milestone success criteria.

For clinical studies, you must provide a summary of:

  • study design
  • study participants
  • study endpoints
  • dose (if applicable)
  • analysis plans

These elements must be directly linked to clear success criteria with defined target and acceptable values.

Additional guidance will be provided in the Funding Service on how to complete this section, including the required format.

For each milestone, using the table format, provide the following details:

  • duration (in months) from project start and from the previous milestone (not applicable for the first milestone, Milestone one)
  • milestone full economic costing (FEC) and cumulative FEC from project start
  • likelihood of meeting the milestone’s criteria
  • objectives
  • measurable success criteria with target and minimum acceptable values for each criterion, along with a justification for these choices

You may include a minimum of two milestones and as many additional milestones as needed for your project.

Data management and sharing

Word limit: 1,500

How will you manage and share data collected or acquired through the proposed research?

What the assessors are looking for in your response

Provide a data management plan which should clearly detail how you will comply with MRC’s published data management and sharing policies, which includes detailed guidance notes.

Provide your response in the text box following the headings in the MRC data management plan template. You are not required to upload the document to your application.

The length of your plan will vary depending on the type of study being undertaken:

  • population cohorts; longitudinal studies; genetic, omics and imaging data; biobanks, and other collections that are potentially a rich resource for the wider research community: maximum of 1,500 words
  • all other research, less complex, the plan may be as short as 500 words

Applicant and team capability to deliver

Word limit: 2,200

Why are you the right individual or team to successfully deliver the proposed work?

What the assessors are looking for in your response

Evidence of how you, and if relevant your team, have:

  • the relevant experience (appropriate to career stage) to deliver the proposed work
  • the right balance of skills and expertise to cover the proposed work
  • the appropriate leadership and management skills to deliver the work and your approach to develop others
  • contributed to developing a positive research environment and wider community

You may demonstrate elements of your responses in visual form if relevant. Further details are provided in the Funding Service.

The word limit for this section is 2,200 words: 1,700 words to be used for Résumé for Research and Innovation (R4RI) modules (including references) and, if necessary, a further 500 words for Additions.

Use the R4RI format to showcase the range of relevant skills you and, if relevant, your team (project lead and project co-leads, researchers, technicians, specialists, partners and so on) have and how this will help deliver the proposed work. You can include individuals’ specific achievements but only choose past contributions that best evidence their ability to deliver this work.

Complete this section using the R4RI module headings listed. Use each heading once and include a response for the whole team, see the UKRI guidance on R4RI. You should consider how to balance your answer, and emphasise where appropriate the key skills each team member brings:

  • contributions to the generation of new ideas, tools, methodologies, or knowledge, this may include your previous funding and key outputs such as publications
  • the development of others and maintenance of effective working relationships
  • contributions to the wider research and innovation community
  • contributions to broader research or innovation users and audiences and towards wider societal benefit, including public partnerships
Additions

Provide any further details relevant to your application. This section is optional and can be up to 500 words. You should not use it to describe additional skills, experiences, or outputs, but you can use it to describe any factors that provide context for the rest of your R4RI (for example, details of career breaks if you wish to disclose them).

Complete this as a narrative. Do not format it like a CV.

References may be included within this section.

The roles in funding applications policy has descriptions of the different project roles.

Project partners

You must add details about your project partner(s) contributions to this section.

A project partner is a collaborating third party organisation who will have an integral role in the proposed research. This may include direct (cash) or indirect (in-kind) contributions such as expertise, staff time or use of facilities. Project partners may be in industry, academia, third sector or government organisations in the UK or overseas, including partners based in the EU.

This funding opportunity requires at least one industry or company partnership. Applications that do not include an industry or company project partner will be rejected. Therefore, you will also need to complete the ‘Industry Collaboration Framework (ICF)’ section. Find out more about ICF.

You must ensure that any third party individual or organisation you include within the Funding Service as a project partner, also provides you with a supporting email or letter of support (see next section ‘Project partners: letters or emails of support’).

The individual named as the project partner contact, cannot be included in your application as a member of the core team, in any core team role.

The project partner organisation cannot be an applicant organisation, where any member of the core team is based. For example, you cannot include a different department based within the applicant organisation as a project partner.

If an individual or organisation outside the core team is responsible for recruitment of people as research participants or providing human tissue for this project, list them as a project partner.

Add the following project partner details:

  • the organisation name (searchable via a drop-down list or enter the organisation’s details manually, as applicable)
  • the project partner contact name and email address
  • the type of contribution (direct or in-direct) and its monetary value

If there are specific circumstances where project partners do require funding for minor costs such as travel and subsistence, these project partner costs should be claimed and justified within the resources and costs section of your application.

If a detail is entered incorrectly and you have saved the entry, remove the specific project partner record and re-add it with the correct information.

For audit purposes, UKRI requires formal collaboration agreements to be put in place if an award is made.

Project partners: letters (or emails) of support

Upload a single PDF containing the letters or emails of support from each partner you named in the ‘Project partners’ section. These should be uploaded in English or Welsh only.

What the assessors are looking for in your response

If you do not have any project partners, you will be able to indicate this in the Funding Service.

What supporting statements we are looking for

We are looking for you to provide letters or emails of support from all your identified project partners.

What we are not looking for

We don’t want any other letters (or emails) of support, from people who are not your identified project partners, such as those simply expressing general support for your project. If these are included by you, they will be ignored by us and will not be used in the assessment process.

Important information

You should only provide letters or emails of support from people you have identified in the project partner section of your application, who will have an integral role in your proposed research.

What each project partner letter or email of support must include

Each project partner letter or email you provide should:

  • include the name of the project partner organisation and contact information
  • explain the project partners’ commitment to the project
  • explain the value, relevance, and possible benefits of the proposed work, to them
  • describe any additional value they will bring to the project
  • not exceed two sides of A4 per project partner

Project partner letters and emails of support are not required to be on headed paper or include handwritten signatures (electronic signatures are acceptable).

The Funding Service will provide document upload details when you apply.

Project partners from industry or a company

Industry or company project partners are required to download and complete the industry or company letter of support template.

Project partners responsible for recruiting research participants or providing human tissue or samples

If the project partner is responsible for the recruitment of people as research participants or providing human tissue their letter or email of support should include:

  • agreement that the project partner will recruit the participants or provide tissue
  • confirmation that what is being supplied is suitable for the proposed work
  • confirmation that the quantity of tissue being supplied is suitable, but not excessive for achieving meaningful results (if applicable)
Agreement with your project partners

Ensure you have prior agreement from project partners so that, if you are offered funding, they will support your project as indicated in the ‘Project partners’ section.

For audit purposes, UKRI requires formal collaboration agreements to be put in place if an award is made.

Industry Collaboration Framework (ICF)

Word limit: 1,500

Include details of your collaboration with your industry or company project partner(s)?

What the assessors are looking for in your response

The assessors are looking for you to confirm that your proposed work involves collaboration with an industry or company project partner. You will need to follow the MRC Industry Collaboration Framework (ICF).

By ‘industry or company’ we mean an enterprise that puts or has intention to put goods or services on a market.

You should explore the ICF decision tree and find out more about ICF which includes:

  • collaboration agreements
  • definitions of basic or applied research
  • internationally based companies
  • subsidy control
  • intellectual property (IP) arrangements
  • fully flexible and gated contributions
  • the ICF assessment criteria

Enter ‘Yes’ in the text box that you have industry or company project partners and you are likely to follow ICF. You should also confirm you’re answers to the ICF questions one to nine in the text box for each ICF project partner.

Contact PPexpmed@mrc.ukri.org if you are unsure if your application should follow ICF.

In addition to the project partner information completed in the previous section, the assessors are looking for information relating to the nature, goals and conditions of the collaboration and any restrictions or rights to the project results that could be claimed by the industry or company project partner.

Confirm your answers to the ICF questions in the text box, repeat this process for each ICF project partner:

  1. Name the industry or company project partner considered under ICF.
  2. Indicate whether your application is basic research or applied research.
  3. Explain why, in the absence of the requested UKRI funding, the collaboration and the planned research could not be undertaken.
  4. State whether your application is under the category of fully flexible contribution or gated contribution (based on the IP sharing arrangements with the industry or company).
  5. Outline the pre-existing IP (‘background IP’) that each partner, including the academic partner, will bring to the collaborative research project and the terms under which partners may access these assets.
  6. Outline the IP that is expected to be developed during the collaborative research project (‘foreground IP’) and briefly outline how it will be managed, including:
    • who will own this IP
    • what rights industry or company partners will have to use academically-generated foreground IP during and after the research project, for internal research and development or for commercial purposes
    • any rights of the academic partner to commercialise the foreground IP, including foreground IP generated by industry or company partners
  7. Outline any restrictions to dissemination of the project results, including the rights of the industry or company partner to:
    • review, approve or delay publications (including the time period associated with such rights)
    • request or require the removal of any information
  8. Declare any conflicts of interest held by the applicants in relation to the industry or company project partners and describe how they will be managed.
  9. Justify collaborating with an overseas industry or company under ICF (if applicable).

Failure to provide the information requested for industry or company partners under ICF could result in your application being rejected.

You are recommended to discuss the goals and conditions of any collaboration with an industry or company with your technology transfer or contracts office before applying.

For audit purposes, UKRI requires formal collaboration agreements to be put in place if an award is made. You must provide us with a copy of the collaboration agreement, signed by all partners, before an ICF award starts.

If this does not apply to your proposed work, you will be able to indicate this in the Funding Service.

Ethics and responsible research and innovation (RRI)

What are the ethical and RRI considerations, implications and issues relating to the proposed work? If you do not think that the proposed work raises any ethical or RRI issues, explain why.

What the assessors are looking for in your response

Demonstrate that you have identified and evaluated:

  • the relevant ethical and RRI considerations, including both the research or topic area itself and the design and delivery of the project
  • the wider implications of the proposed work, and how you will maximise the positive societal, environmental, and economic benefits arising from the project, whilst minimising unintended negative impacts, such as research misuse or accidental harm
  • how you will manage these considerations throughout the lifecycle of the project

You may demonstrate elements of your responses in visual form if relevant. Further details are provided in the Funding Service.

Please refer to the UKRI position statement on funding ethical research and Responsible innovation for more information around our expectations on ethical and responsible research and innovation.

Animal involvement and “3Rs”

You must complete this section about how your proposed project will involve or impact animals.

If your project does not involve or impact animals, you must confirm this on the next page.

You may be asked about:

  • what animals you are involving
  • the severity of the procedures you are using
  • where the procedures will take place
  • welfare standards you aim to meet
  • the relevance of your project to the development, validation or dissemination of the 3Rs

You may also need to download, complete, and upload at least one set of additional questions. You will be told how to do this towards the end of this section.

To complete this section and check whether your project is in the scope of the questions, refer to the UKRI policy on research and innovation involving animals.

What counts as an animal

UKRI policy relates to all animals in the Kingdom Animalia, including vertebrates and invertebrates.

Genetically modified organisms and biological risk

You must complete this section if your project will include genetically modified organisms or genetic technologies.

If you project does not involve genetically modified organisms or genetic technologies, you must confirm this on the next page.

You may be asked about:

  • the type of organism your project will involve and the procedures your project will include
  • the intended use of the organism or genetic technology
  • the genetic, biological and environmental risks of your project

For more information, see UKRI’s guidance on genetic technologies.

Human participation in health-related research

You must complete this section about whether your project will include human participation.

If your project does not involve human participation, you must confirm this on the next page.

You may be asked about:

  • what type of human participation your project includes
  • the project design for human participation
  • the phase of the clinical trial
  • whether the project will be in an NHS setting, if so how the project will be registered
  • whether diversity and inclusion will be considered

For more information, see UKRI’s guidance for human participants in research.

Resources and cost justification

Word limit: 1,000

What will you need to deliver your proposed work and how much will it cost?

What the assessors are looking for in your response

Justify the application’s more costly resources, in particular:

  • project staff
  • significant travel for field work or collaboration (but not regular travel between collaborating organisations or to conferences)
  • any equipment that will cost more than £25,000
  • any consumables beyond typical requirements, or that are required in exceptional quantities
  • all facilities and infrastructure costs
  • all resources that have been costed as ‘Exceptions’
  • support for international co-leads, demonstrating this is within the 30% costs cap for co-leads from high-income countries, India and China. There is no cap on costs requested for international applicants from DAC list countries
  • NHS research costs, when they are associated with NHS studies
  • any work to be outsourced, including the reason for outsourcing, scope, provider and cost
  • support for public and patient involvement and engagement. See payments to public partners

You can request costs associated with reasonable adjustments where they increase as a direct result of working on the project. For further information see Disability and accessibility support for UKRI applicants and grant holders. Where a funding limit is imposed on the opportunity, requested costs for reasonable adjustments may exceed the maximum funding amount.

Assessors are not looking for detailed costs or a line-by-line breakdown of all project resources. Overall, they want you to demonstrate how the resources you anticipate needing for your proposed work:

  • are comprehensive, appropriate, and justified
  • represent the optimal use of resources to achieve the intended outcomes
  • maximise potential outcomes and impacts

Trusted Research and Innovation (TR&I)

Trusted Research and Innovation is the protection of the UK’s intellectual property, sensitive research, people, and infrastructure from potential theft, misuse, and exploitation.

Organisations receiving UKRI funding are obliged to act in line with UK government legislation. They are also expected to undertake appropriate due diligence assessments of organisations involved in research partnerships, collaboration agreements, and commercial contracts.

You will be asked about:

  • which areas of the National Security and Investment (NSI) Act your project relates to
  • who you intend to collaborate with and how
  • if your project requires an export control licence

Your answers may affect the T&Cs of your funding agreement if you are successful. We may use your answers to determine that our current T&Cs are sufficient or if additional T&Cs are required.

How we will assess your application

Assessment process

We will assess your application using the following process.

Expert review

We will invite experts to review your application independently, against the specified criteria for this funding opportunity.

You will not be able to nominate reviewers for applications on the new UK Research and Innovation (UKRI) Funding Service. Research councils will continue to select expert reviewers.

We are monitoring the requirement for applicant-nominated reviewers as we review policies and processes as part of the continued development of the new Funding Service.

A shortlisting stage may take place at this stage.

Applicant response

When expert review has been completed for your application, you will have 14 calendar days to respond to reviewers’ comments.

If you’re unable to provide your response, you can nominate one of your project co-leads named on your application. Your nominated project co-lead will need to contact your research office to enter the response into the Funding Service.

Please note that extensions for responding to reviewer comments will only be considered in exceptional circumstances, where equality, diversity, or inclusion considerations apply.

Panel meeting

The next stage of assessment is a panel meeting. An expert panel will score and prioritise your application and make recommendations for funding.

This stage may take the form of interviews. This will be confirmed by email to all applicants. We will contribute towards the cost of your return travel to attend the interview, modest subsistence costs and reasonable additional family care costs. We will endeavour to offer virtual interviews if required.

We expect the panel meeting to be held on 24 and 25 February 2027. This will be confirmed by email to all applicants.

MRC will make the final funding decision.

Find out more about MRC’s assessment process.

For more information on how we prioritise applications for funding please visit How we make decisions.

We reserve the right to modify the assessment process as needed.

Feedback

We will notify of you of the outcome of your application within 10 working days of the panel meeting. We will give feedback on your application within eight weeks of the panel meeting.

Principles of assessment

We support the San Francisco declaration on research assessment and recognise the relationship between research assessment and research integrity.

Find out about the UKRI principles of assessment and decision making.

Using generative artificial intelligence (AI) in expert review

Generative AI may be used only for the purpose of language refinement during application assessment. When using generative AI to refine the language of a review, expert reviewers and panellists must ensure that:

  • no part of the application being assessed is entered into a generative AI tool
  • no personal information from the application is disclosed
  • generative AI is not tasked with understanding, summarising or evaluating the application’s content

Expert reviewers and panellists must also:

  • comply with relevant intellectual property and data protection legislation
  • not take into account or speculate within their assessment whether generative AI has been used to develop the application

For more detail see our policy on the use of generative AI.

Assessment areas

The assessment areas we will use are:

  • vision of the project and its alignment to the aims of the funding opportunity
  • the intervention
  • capability of the applicants and team to deliver the project including evidence of effective and beneficial partnership with industry
  • ethical and responsible research and innovation considerations of the project
  • resources requested to do the project

We will also assess your approach to your project work, including:

  • project plan and milestones
  • methodology, experimental design
  • reproducibility and statistical design
  • risk mitigation and management
  • research environment and infrastructure
  • plans for patient and public involvement
  • communication and engagement
  • data management and sharing plans

Find details of assessment questions and criteria under the ‘Application questions’ heading in the ‘How to apply’ section.

Contact details

Get help with your application

If you have a question and the answers aren’t provided on this page

The helpdesk is committed to helping users of the UK Research and Innovation (UKRI) Funding Service as effectively and as quickly as possible. In order to manage cases at peak volume times, the helpdesk will triage and prioritise those queries with an imminent opportunity deadline or a technical issue. Enquiries raised where information is available on the Funding finder opportunity page and should be understood early in the application process (for example, regarding eligibility, content or remit of a funding opportunity) will not constitute a priority case and will be addressed as soon as possible.

Contact details

For help and advice on costings and writing your application please contact your research office in the first instance, allowing sufficient time for your organisation’s submission process.

For questions related to this specific funding opportunity please contact PPexpmed@mrc.ukri.org

Any queries regarding the system or the submission of applications through the Funding Service should be directed to the helpdesk.

Email: support@funding-service.ukri.org
Phone: 01793 547490

Our phone lines are open:

  • Monday to Thursday 8:30am to 5:00pm
  • Friday 8:30am to 4:30pm

To help us process queries more efficiently, we request that users highlight the council and opportunity name in the subject title of their email query, include the application reference number, and refrain from contacting more than one mailbox at a time.

For further information on submitting an application read How applicants use the Funding Service.

Additional info

Support for applicants

You are strongly encouraged to engage with your organisation’s Research Governance office who will be able to offer guidance and support.

Guidance is available on the MRC Regulatory Support Centre, developed in collaboration with the Health Research Authority, for those conducting research with human participants, their tissues or data.

The vast majority of studies that involve human participants, their tissues or data should undergo a research ethics committee (REC) review and many research studies may require an NHS REC opinion. The Health Research Authority Decision Tool can be used to determine whether your study requires this type of approval.

The Integrated Research Application System (IRAS) should be used when applying for NHS REC approval and for other regulatory approvals. IRAS is a single system for applying for the permissions and approvals for health and social/community care research in the UK.

Ethics and regulatory approval

We do not require ethics permissions and regulatory approvals to be in place when you submit an application. However, given that research involving human subjects or requiring the use of human tissue or organs may raise various ethical and regulatory issues, you will be required to demonstrate that you have adequately considered these matters.

Early discussions with regulatory bodies are advised to ensure that all requirements can be met in a timely manner. Once an application is successful, it is the responsibility of the host organisation to ensure that the appropriate ethics and regulatory approval has been obtained and that no research requiring such approval is initiated before it has been granted.

Resources

You may find the following organisations and resources useful when preparing an application.

The National Institute for Health and Care Research (NIHR) provides a clinical trials toolkit that gives practical advice to those planning or running clinical trials in the UK.

If you are considering a drug repurposing project you may wish to explore the Repurposing Medicines Toolkit, developed by MRC and LifeArc.

Research and innovation impact

Impact can be defined as the long-term intended or unintended effect research and innovation has on society, economy and the environment; to individuals, organisations, and the wider global population.

Pre-recorded video for potential applicants

This recording provides more information about the funding opportunity and answers frequently asked questions.

Watch the pre-recorded video.

Research disruption due to COVID-19

We recognise that the COVID-19 pandemic has caused major interruptions and disruptions across our communities. We are committed to ensuring that individual applicants and their wider team, including partners and networks, are not penalised for any disruption to their career, such as:

  • breaks and delays
  • disruptive working patterns and conditions
  • the loss of ongoing work
  • role changes that may have been caused by the pandemic

Reviewers and panel members will be advised to consider the unequal impacts that COVID-19 related disruption might have had on the capability to deliver and career development of those individuals included in the application. They will be asked to consider the capability of the applicant and their wider team to deliver the research they are proposing.

Where disruptions have occurred, you can highlight this within your application if you wish, but there is no requirement to detail the specific circumstances that caused the disruption.

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